5-Aminobenzimidazole → HCID 178446913, Verbindung

HRID 452063

Reaktionsgleichung

Reaktionsgleichung von HRID 452063
FC(F)(F)C([O-])=O.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]2[N:13]=[CH:14][NH:15][C:11]=2[CH:10]=1.[CH2:18]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1)[CH2:19][CH2:20][CH2:21][CH3:22].[Si](C#N)(C)(C)C.[N:38]1([C:43](N2C=CN=C2)=[O:44])C=CN=[CH:39]1>>[NH:13]1[C:12]2[CH:16]=[CH:17][C:9]([N:8]3[CH:28]([C:27]4[CH:30]=[CH:31][C:24]([O:23][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:25][CH:26]=4)[CH2:39][NH:38][C:43]3=[O:44])=[CH:10][C:11]=2[N:15]=[CH:14]1

Komponenten

6

Edukt 5

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 79815p-PentoxybenzaldehydeHCID 82115Trimethylsilyl cyanideHCID 84468Trifluoroacetate

Produkt 1

HCID 178446913HCID 178446913, Verbindung

Versuchsvorschrift

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 4-pentoxybenzaldehyde (0.755 mL, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.05 mL, 7.4 mmol), di-(imidazol-1-yl)methanone (0.667 g, 4.12 mmol) as described in method 2. The product was purified by means of preparative HPLC.

Aufarbeitung

  1. customThe product was purified by means of preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-fef5e30579e3444089a7a1150f520b34
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486940B2

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