5-Aminobenzimidazole → HCID 51030962, Verbindung

HRID 452071

Reaktionsgleichung

Reaktionsgleichung von HRID 452071
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[O:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][O:19][C:20]2[CH:27]=[CH:26][C:23]([CH:24]=O)=[CH:22][CH:21]=2)[CH2:13][CH2:12]1.[Si](C#N)(C)(C)C.[N:34]1([C:39](N2C=CN=C2)=[O:40])C=CN=[CH:35]1>>[O:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][O:19][C:20]2[CH:27]=[CH:26][C:23]([CH:24]3[N:1]([C:2]4[CH:10]=[CH:9][C:5]5[N:6]=[CH:7][NH:8][C:4]=5[CH:3]=4)[C:39](=[O:40])[NH:34][CH2:35]3)=[CH:22][CH:21]=2)[CH2:13][CH2:12]1

Komponenten

5

Edukt 4

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanideHCID 37199024-(2-Morpholinoethoxy)benzaldehyde

Produkt 1

HCID 51030962HCID 51030962, Verbindung

Versuchsvorschrift

The compound was synthesized as ditrifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 4-(2-morpholinoethoxy)benzaldehyde (0.941 g, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.34 mL, 9.6 mmol), di-(imidazol-1-yl)methanone (0.582 g, 3.6 mmol) as described in method 2. The product was purified by means of preparative HPLC.

Aufarbeitung

  1. customThe product was purified by means of preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-a09b34d2006140fb960c4f057a2d045f
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486940B2

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