Reaktionsgleichung
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)=[CH2:2].[C:15](=[O:20])([O:17]CC)[NH2:16].C[C:22]1([CH3:29])[NH:26][C:25](=O)[NH:24][C:23]1=O.[CH3:30][CH2:31][C@H:32]1[C@H]2C[C@H]([C@H](OC3C4C(=CC=CC=4)C(O[C@H](C4C=CN=C5C=4C=C(OC)C=C5)[C@@H]4N5C[C@H](CC)[C@@H](CC5)C4)=NN=3)C3C=CN=C4C=3C=C(OC)C=C4)N(CC2)C1.[OH-].[Na+].IC1C=C(N)C(N)=CC=1.[F-].[Cs+].C1(N)CCCCC1N>[Cu]I.C(OCC)(OCC)OCC>[NH:26]1[C:22]2[CH:29]=[C:30]([N:16]3[C@@H:1]([C:3]4[CH:8]=[CH:7][C:6]([C:9]5[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=5)=[CH:5][CH:4]=4)[CH2:2][O:17][C:15]3=[O:20])[CH:31]=[CH:32][C:23]=2[N:24]=[CH:25]1Komponenten
11
Edukt 8
HCID 46101,2-Diaminocyclohexane
HCID 5641Carbamic acid, ethyl ester
HCID 6491Dimethylhydantoin
HCID 14798Sodium Hydroxide
HCID 16883p-Vinylbiphenyl
HCID 25953Cesium fluoride
HCID 112070494-Iodobenzene-1,2-diamine
HCID 510036741-((1R)-((2R,4R,5S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)-4-((1R)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazineProdukt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
The compound was synthesized starting from 4-vinylbiphenyl (1.55 g 8.6 mmol), ethyl carbamate (2.38 g, 26.7 mmol), 5,5-dimethylimidazolidine-2,4-dione (2.6 g, 13.2 mmol), (DHQ)2PHAL (0.402 g, 0.52 mmol), K2OsO4x2H2O (0.127 g, 0.34 mmol), 0.38 M aqueous NaOH (74 mL, 28 mmol), 4-iodobenzene-1,2-diamine (0.35 g, 1.5 mmol), copper(I) iodide (0.029 g, 0.15 mmol), cesium fluoride (0.456 g, 3 mmol), cyclohexane-1,2-diamine (0.018 mL, 0.15 mmol), triethyl orthoformate (10 ml) as described in method 5.
Aufarbeitung
- customThe compound was synthesized
Quellen und Nachweise
- ORD-Eintrag
- ord-c93325d0d6f54034b348d348ee8900df
- Quelldatensatz
- uspto-grants-2013_07
- Patentnummer
- US08486940B2
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