Water → 2-(methoxymethyl)-1H-benzimidazole

HRID 452189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 452189
Cl[CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[CH3:12][OH:13].C[O-].[Na+].O>CO>[CH3:12][O:13][CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 785712-ChloromethylbenzimidazoleHCID 23694274Sodium methanolate methanol

Produkt 1

HCID 2429502-(methoxymethyl)-1H-benzimidazoleAusbeute 19 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Chloromethylbenzimidazole (1.67 g, 10 mmol) was suspended in methanol (34 mL), 28% sodium methoxide methanol solution (9.6 mL, 50 mmol) and water (50 mL) were added, and the mixture was stirred at room temperature for 20 min. The precipitated solid was collected by filtration, and purified by silica gel column chromatography (chloroform/methanol=100/0 to 93/7) to give the title compound (303 mg, 19%).

Aufarbeitung

  1. filtrationThe precipitated solid was collected by filtration
  2. custompurified by silica gel column chromatography (chloroform/methanol=100/0 to 93/7)

Quellen und Nachweise

ORD-Eintrag
ord-531e5954d5dc4528ad35a8dfe02b238b
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486980B2

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