Methyl 3-(5-methoxypyridin-3-yl)acrylate → HCID 68844093, Verbindung

HRID 45243

Reaktionsgleichung

Reaktionsgleichung von HRID 45243
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:9]=[CH:10]/[C:11]([O:13][CH3:14])=[O:12])[CH:6]=[N:7][CH:8]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:6]=[N:7][CH:8]=1

Komponenten

4

Edukt 1

HCID 46736765Methyl 3-(5-methoxypyridin-3-yl)acrylate

Produkt 1

HCID 68844093HCID 68844093, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

In Parr apparatus, a mixture of 1 g (5.33 mmol) of methyl (2E)-3-(5-methoxypyridin-3-yl)prop-2-enoate in 20 mL of MeOH and 0.1 g of 10% Pd/C is hydrogenated at 7 bar for 5 hours. The reaction mixture is then filtered through Whatman GF/F paper and concentrated under reduced pressure. 1 g of methyl 3-(5-methoxypyridin-3-yl)propanoate is thus obtained in the form of a wax, which is used without further purification in the following step.

Aufarbeitung

  1. filtrationThe reaction mixture is then filtered through Whatman GF/F paper
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6ce0145da8c3440ca591256bc20caa1e
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541455B2

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