Potassium Carbonate → 2,6-dichloro-9-cyclohexyl-9H-purine

Beteiligte Stoffe

Reaktionsschritte

2,6-Dichloropurine (1 mmol), powdered potasium carbonate (1 mmol) and cyclohexyliodide (4 mmol) were vigorously stirred in 5 mL DMSO overnight. After evaporation of the solvent the product was extracted (water/diethylether) and purified by column chromatography (silicagel/1% MeOH in CHCl3). Crystallization from methanol gave the product in yield 41%, mp 116-121° C.

Herkunft & Nachweise