反应详情

2,6-Dichloropurine (1 mmol), powdered potasium carbonate (1 mmol) and cyclohexyliodide (4 mmol) were vigorously stirred in 5 mL DMSO overnight. After evaporation of the solvent the product was extracted (water/diethylether) and purified by column chromatography (silicagel/1% MeOH in CHCl3). Crystallization from methanol gave the product in yield 41%, mp 116-121° C.

1. customAfter evaporation of the solvent the product
2. extractionwas extracted (water/diethylether)
3. custompurified by column chromatography (silicagel/1% MeOH in CHCl3)
4. customCrystallization from methanol
5. customgave the product in yield 41%, mp 116-121° C.