Ammonia → 5-Bromo-2-(trifluoromethyl)pyrimidine

A mixture of potassium fluoride (1.77 g) and cuprous iodide (5.79 g) was stirred and heated together using a heat gun under vacuum (˜1 mm) for 20 min. After cooling, dimethyl formamide (20 ml) and N-methylpyrrolidinone (20 ml) were added followed by (trifluoromethyl)trimethylsilane (4.1 ml) and 5-bromo-2-iodopyrimidine (6.5 g). The mixture was stirred at rt for 5 h and then the brown solution was poured into 6N ammonia solution. The product was extracted into ethyl acetate and the extracts were washed with sodium bicarbonate solution and brine and then dried (Na2SO4) and evaporated. Chromatography on silica gel (elution with 20-50% dichloromethane in pentane) gave the title compound (D13) as a white solid (2.4 g). 1H NMR (CDCl3): 8.97 (2H, s).

1. temperatureheated together
2. customfor 20 min
3. temperatureAfter cooling
4. stirringThe mixture was stirred at rt for 5 h
5. extractionThe product was extracted into ethyl acetate
6. washthe extracts were washed with sodium bicarbonate solution and brine
7. dry with materialdried (Na2SO4)
8. customevaporated

ORD-Eintrag

ord-5a9c459d47ab462eb3a52a66414054c5

Quelldatensatz

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08492375B2