Metformin Hydrochloride → HCID 178476642, Verbindung

HRID 45300

Reaktionsgleichung

Reaktionsgleichung von HRID 45300
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.O.O.O.[C:14]([O-:17])(=[O:16])[CH3:15].[Na+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:14]([O-:17])(=[O:16])[CH3:15]

Komponenten

4

Edukt 2

HCID 14219Metformin HydrochlorideHCID 23665404Sodium Acetate Trihydrate

Produkt 1

HCID 178476642HCID 178476642, VerbindungAusbeute 51,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

20.0 g (1 equivalent) of metformin hydrochloride, 50 Ml of water, and 19.72 g (1.2 equivalents) of sodium acetate trihydrate were added to a reactor, and stirred. Then the resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 11.72 g of metformin acetate (yield: 51.3%).

Aufarbeitung

  1. filtrationThen the resulting crystal was filtered
  2. washwashed with acetone
  3. customdried at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-8f6f02ec54e8446e91f4b5525381d122
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541474B2

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