Acetone → HCID 178476642, Verbindung

HRID 45301

Reaktionsgleichung

Reaktionsgleichung von HRID 45301
[OH2:1].[OH-].[Na+].[CH3:4][N:5]([C:7]([N:9]=[C:10]([NH2:12])[NH2:11])=[NH:8])[CH3:6].Cl.C[C:15]([CH3:17])=[O:16]>>[CH3:4][N:5]([C:7]([NH:9][C:10]([NH2:12])=[NH:11])=[NH:8])[CH3:6].[C:15]([O-:1])(=[O:16])[CH3:17]

Komponenten

5

Edukt 4

HCID 180AcetoneHCID 962WaterHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 178476642HCID 178476642, VerbindungAusbeute 92,4 %

Versuchsvorschrift

0.4 L of water, 241.50 g of sodium hydroxide, 9 L of acetone and 1 Kg of metformin hydrochloride were added to a 20 L reactor, and stirred for 2 hours and 40 minutes at room temperature. The resulting crystal was filtered and washed with acetone. 0.2 L of water and 1 L of acetic acid were added and stirred. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 1,056 g of metformin acetate (yield: 92.4%).

Aufarbeitung

  1. filtrationThe resulting crystal was filtered
  2. washwashed with acetone
  3. addition0.2 L of water and 1 L of acetic acid were added
  4. stirringstirred
  5. filtrationThe resulting crystal was filtered
  6. washwashed with acetone
  7. customdried at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-050d89d8ac0a418c87d5623f7c8d671e
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541474B2

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