Acetic Acid → HCID 178476642, Verbindung

HRID 45304

Reaktionsgleichung

Reaktionsgleichung von HRID 45304
[C:1]([OH:4])(=[O:3])[CH3:2].[CH3:5][N:6]([C:8]([NH:10][C:11]([NH2:13])=[NH:12])=[NH:9])[CH3:7]>CC(C)=O>[CH3:5][N:6]([C:8]([NH:10][C:11]([NH2:13])=[NH:12])=[NH:9])[CH3:7].[C:1]([O-:4])(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 178484382HCID 178484382, Verbindung

Produkt 1

HCID 178476642HCID 178476642, VerbindungAusbeute 59,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

20.00 g (1 equivalent) of metformin hydrochloride and 4.84 g (1 equivalent) of sodium hydroxide were stirred in 200 Ml of ethanol for 2 hours at room temperature, and then remaining solid was filtered and the filtrate was concentrated under reduced pressure. Then 300 Ml of acetone was added to the resulting solid and stirred. Insoluble material was filtered, and the filtrate was concentrated under reduced pressure to obtain 12.0 g of metformin free base. 500 Ml of acetone and 10 Ml (1.45 equivalents) of glacial acetic acid were added to the metformin free base, and then the mixture was stirred. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 13.6 g of metformin acetate (yield: 59.5%).

Aufarbeitung

  1. filtrationThe resulting crystal was filtered
  2. washwashed with acetone
  3. customdried at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-093ce2a18d824f30afe9cc2c2caeab94
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541474B2

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