Hydrochloric Acid → Metformin Hydrochloride

HRID 45306

Reaktionsgleichung

Reaktionsgleichung von HRID 45306
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[ClH:10]>CC(C)=O>[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].[ClH:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 178484382HCID 178484382, Verbindung

Produkt 1

HCID 14219Metformin HydrochlorideAusbeute 76,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).

Aufarbeitung

  1. filtrationThe resulting crystal was filtered
  2. washwashed with acetone
  3. customdried
  4. temperaturewith heated air at 70° C.

Quellen und Nachweise

ORD-Eintrag
ord-bb7f28c0f0144c43ad84ff9519be4688
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541474B2

Verknüpfte Notizen

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