Hydrochloric Acid → HCID 67369868, Verbindung

HRID 453895Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 453895
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][C:12]([N:20]([CH3:22])[CH3:21])([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.O.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[ClH:1].[ClH:1].[CH3:21][N:20]([CH3:22])[C:12]1([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 10340Sodium CarbonateHCID 57831240HCID 57831240, Verbindung

Produkt 1

HCID 67369868HCID 67369868, VerbindungAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

HCl gas was passed through a solution of 10 g (1 eq.) tert-butyloxycarbonyl-4-(dimethylamino)-4-(thiophen-2-yl)piperidine in chloroform at 0° C. for ±1 h. Once the conversion was complete, 200 ml water were added to the reaction mixture, it was adjusted to a pH of ˜8 with Na2CO3 and then extracted with 15% IPA/CHCl3. The combined organic phases were dried over Na2SO4. Following removal of the solvent under reduced pressure, 6 g (89%) of product were obtained in the form of a white solid.

Aufarbeitung

  1. extractionextracted with 15% IPA/CHCl3
  2. dry with materialThe combined organic phases were dried over Na2SO4
  3. customremoval of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1f62bc45d2724fc5baafc8e0d02ca516
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492559B2

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