Citric Acid → 5-(Furan-3-yl)pyridine-3-carboxylic acid

HRID 454527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 454527
[OH-].[Na+].[O:3]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:14]([O:16]C)=[O:15])[CH:11]=[N:12][CH:13]=2)=[CH:4]1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>CO>[O:3]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:14]([OH:16])=[O:15])[CH:11]=[N:12][CH:13]=2)=[CH:4]1

Komponenten

5

Edukt 3

HCID 311Citric AcidHCID 14798Sodium HydroxideHCID 66989989Methyl 5-(furan-3-yl)pyridine-3-carboxylate

Produkt 1

HCID 639483225-(Furan-3-yl)pyridine-3-carboxylic acidAusbeute 65,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A 4 mol/L aqueous solution of sodium hydroxide (2.0 mL) was added to a methanol (10 mL) solution of methyl 5-(furan-3-yl)pyridine-3-carboxylate (0.54 g) at room temperature, followed by stirring at the same temperature for 2 hours and 50 minutes. A 10% aqueous solution of citric acid (8 mL) was added to the reaction mixture at room temperature, and the solvent was evaporated under reduced pressure. Water was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.33 g of 5-(furan-3-yl)pyridine-3-carboxylic acid as a light yellow solid.

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. additionWater was added to the obtained residue
  3. filtrationthe solid substance was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-0f5757db9a114f4ea4c086d54b75ce06
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08492582B2

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