Uracil → 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
Reaktionsgleichung
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[NH:20]1[CH:25]=[CH:24][C:23](=[O:26])[NH:22][C:21]1=[O:27]>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]3[C:4]=2[CH2:3][N:20]2[CH:25]=[CH:24][C:23](=[O:26])[NH:22][C:21]2=[O:27])=[CH:14][CH:15]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared according to Method B and the experimentals described for compound 91 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and pyrimidine-2,4(1H,3H)-dione. M/e+ 353 for C18H14ClN4O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.33 (d, J=5.8 Hz, 1H), 8.10 (s, 1H), 7.81 (d, J=8.4 Hz, 1H), 7.63 (d, J=8.4 Hz, 2H), 7.51 (d, J=8.4 Hz, 2H), 7.39 (td, J=6.9, 1.1 Hz, 1H), 7.00 (td, J=6.9, 1.1 Hz, 1H), 6.66 (d, J=8.0 Hz, 1H), 5.58 (d, J=8.0 Hz, 1H), 5.45 (s, 2H) ppm.
Quellen und Nachweise
- ORD-Eintrag
- ord-299f2099154143fb9b501c5c6e0121eb
- Quelldatensatz
- uspto-grants-2013_07
- Patentnummer
- US08497278B2
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