Hydrochloric Acid → Hydrochloric Acid

HRID 455351Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 455351
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C:2]=12.[ClH:14]>O=[Pt]=O.C(O)C>[NH:1]1[CH2:6][CH2:5][CH2:4][C@@H:3]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C@H:2]12.[ClH:14]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 12226515Azafluorene

Produkt 2

HCID 313Hydrochloric AcidHCID 58123900cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysator2×HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 9H-indeno[2,1-b]pyridine (0.20 g), PtO2 (70 mg), concentrated aqueous hydrochloric acid (0.1 mL), and ethanol (10 mL) is shaken under hydrogen atmosphere (2 bar) at room temperature for 16 h (in case the transformation is not complete after this time another portion of PtO2 (30 mg) is added and shaking under hydrogen is continued until complete). The catalyst is separated by filtration and the solvent is evaporated to give the crude title compound as its hydrochloric acid salt that is used without further purification. Yield: 0.25 g (crude); Mass spectrum (ESI+): m/z=174 [M+H]+.

Aufarbeitung

  1. additionis added
  2. stirringshaking under hydrogen
  3. customThe catalyst is separated by filtration
  4. customthe solvent is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a291dfe5e6b84b33b800681e91238d5f
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08497281B2

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