Morpholine → 2-Fluoro-4-morpholinobenzonitrile

HRID 45608Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 45608
[F:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>O1CCCC1>[F:1][C:2]1[CH:9]=[C:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 775452,4-Difluorobenzonitrile

Produkt 1

HCID 210699252-Fluoro-4-morpholinobenzonitrileAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 2,4-difluorobenzonitrile (6.03 g, 43.35 mmol) and morpholine (8.3 ml, 95.17 mmol) in tetrahydrofuran (27 ml) was stirred at room temperature for 24 hr. The mixture was evaporated and the white solid purified by Biotage™ column (90 g, silica) eluting with cyclohexane:ethyl acetate: (4:1) to give 2-fluoro-4-(morpholino)-benzonitrile as a white solid (5.81 g, 65%).

Aufarbeitung

  1. customThe mixture was evaporated
  2. customthe white solid purified by Biotage™ column (90 g, silica)
  3. washeluting with cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-fe7c453dc1e84ed48bb0650f1f54c9d5
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541579B2

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