Hydrazine hydrate (1:1) → 1-(Quinolin-6-yl)cyclopropanecarbohydrazide

HRID 456114Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 456114
C[O:2][C:3]([C:5]1([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[CH:13][CH:12]=[CH:11]3)[CH2:7][CH2:6]1)=O.O.[NH2:19][NH2:20]>CO>[N:14]1[C:15]2[C:10](=[CH:9][C:8]([C:5]3([C:3]([NH:19][NH2:20])=[O:2])[CH2:7][CH2:6]3)=[CH:17][CH:16]=2)[CH:11]=[CH:12][CH:13]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 58190477Methyl 1-(quinolin-6-yl)cyclopropanecarboxylate

Produkt 1

HCID 669271581-(Quinolin-6-yl)cyclopropanecarbohydrazideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-quinolin-6-yl-cyclopropanecarboxylic acid methyl ester (513 mg, 2.26 mmol) and hydrazine monohydrate (3.39 g, 67.7 mmol) in methanol (5 mL) was heated under reflux overnight. After cooling, the solvent was removed in vacuo to afford 513 mg (100%) of the title compound and used without further purification. LCMS (method A): [MH]+=228, tR=2.88 min.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a43a402029b649049326699f8de4c99d
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08497368B2

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