Dimethyl malonate → 2-Diazonio-1,3-dimethoxy-3-oxoprop-1-en-1-olate

Temperatur

39 °C

9.9 g. (0.075 mole) of dimethyl malonate, 50 ml of anhydrous acetonitrile, and 7.6 g (0.075 mole) of triethylamine (b.p. 88.5-90.5° C.) were added to a 300 ml double-jacketed flask with a dropping funnel, reflux condenser and mechanical stirrer (Rushton). The temperature of the mixture was adjusted to 20° C., and 14.8 g (0.075 mole) of p-toluenesulfonyl azide in 50 ml of CH3CN is added dropwise with vigorous stirring over 15 minutes. The addition caused the reaction mixture to warm to 38-40° C. and assume a yellow colour. After the mixture had been stirred at room temperature for 2.5 hours, the solvent was evaporated at 35° C. (12 mm). The partially crystalline residue was triturated with 100 ml of ether, and the mixture, including the insoluble residue, was placed in a 500 ml separatory funnel. The mixture was washed successively with a 50 ml solution of potassium hydroxide (2N) and a 50 ml solution of potassium hydroxide (0.5N) solution. The yellow-orange ethereal phase was dried over anhydrous sodium sulfate, and the solvent evaporated at 35° (15 mm) until the residue had attained a constant weight. The yellow-orange diazo ester weighed 5 g. The product was checked by 1HNMR spectroscopy and found to be ca. 90% pure.

1. temperaturereflux condenser and mechanical stirrer (Rushton)
2. customwas adjusted to 20° C.
3. additionThe addition
4. stirringAfter the mixture had been stirred at room temperature for 2.5 hours
5. customthe solvent was evaporated at 35° C. (12 mm)
6. customThe partially crystalline residue was triturated with 100 ml of ether
7. customwas placed in a 500 ml separatory funnel
8. washThe mixture was washed successively with a 50 ml solution of potassium hydroxide (2N)
9. dry with materialThe yellow-orange ethereal phase was dried over anhydrous sodium sulfate
10. customthe solvent evaporated at 35° (15 mm) until the residue

ORD-Eintrag

ord-12c42106619a4267b49f40db324031d6

Quelldatensatz

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08497384B2