Benzylamine → (3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione
Reaktionsgleichung
[C:1]([OH:10])(=O)[C@@H:2]([C@H:4]([C:6](O)=[O:7])[OH:5])[OH:3].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CC1C=CC=CC=1C>[CH2:11]([N:18]1[C:6](=[O:7])[C@H:4]([OH:5])[C@@H:2]([OH:3])[C:1]1=[O:10])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
L-Tartaric acid (90 g, 600 mmol) and benzylamine (64.3 g, 600 mmol) were mixed in 400 mL of o-xylene and the mixture was refluxed 14 hours with a Dean-Stark trap. The pellet was filtered off and the compound was crystallized from hot EtOH (1600 mL). The formed crystals were washed with cold hexane to afford the title compound.