Nitrogen → 1-(2-Bromoethoxy)-2,4-difluorobenzene

HRID 456424Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 456424
[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:3]=1[O:4][CH2:5][CH2:6]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:33].N#N>C(Cl)Cl.CCOC(C)=O>[Br:33][CH2:6][CH2:5][O:4][C:3]1[CH:8]=[CH:9][C:10]([F:12])=[CH:11][C:2]=1[F:1]

Komponenten

7

Edukt 4

HCID 947NitrogenHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 18437003Ethanol, 2-(2,4-difluorophenoxy)-

Produkt 1

HCID 232942611-(2-Bromoethoxy)-2,4-difluorobenzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a cool solution 2-(2,4-difluoro-phenoxy)-ethanol (0.48 g, 2.77 mmol.) in CH2Cl2 (15 ml), triphenyl phosphine (1.3 g, 5 mmol)) was added. Carbon tetrabromide (1.65 g, 5 mmol.) in CH2Cl2 (3 ml) was added to the solution dropwise under N2. The solution was stirred for 30 minutes. EtOAc was added, then the solvent was evaporated under reduced pressure.

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d2aed284c51e47ada2a87d9c5beb07e7
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07186726B2

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