Lithium Hydroxide → [4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic Acid

HRID 456429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 456429
C([O:3][C:4](=[O:28])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:27])[CH2:13][CH:14]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:8][CH2:7]1)C.[Li+].[OH-]>CO.O>[C:21]1([CH:14]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:13][C:12]([N:9]2[CH2:10][CH2:11][N:6]([CH2:5][C:4]([OH:28])=[O:3])[CH2:7][CH2:8]2)=[O:27])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 58817810[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic Acid Ethyl Ester

Produkt 1

HCID 18437004[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic AcidAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

A mixture of [4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic acid ethyl ester (1.17 g, 3.07 mmol) and LiOH (645 mg, 15.35 mmol) in MeOH: H2O (3:1, 40 ml) stirred at room temperature for 2 days. The solvent was then evaporated and residue dissolved in water. Upon acidified with 2N HCl to pH 3, product precipitated in aq. phase, filtered and washed few times with water and dried to give the desired product in 78% yield.

Aufarbeitung

  1. customThe solvent was then evaporated
  2. dissolutionresidue dissolved in water
  3. customprecipitated in aq. phase
  4. filtrationfiltered
  5. washwashed few times with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ab4b2667b017452a9e359a6229a1bf05
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07186726B2

Notizen zur Reaktion

Wird geladen…