Triethylamine → 3,4-Methylenedioxyphenethyl mesylate

HRID 456587

Reaktionsgleichung

Reaktionsgleichung von HRID 456587
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][OH:12])=[CH:9][C:4]=2[O:3][CH2:2]1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])=[CH:9][C:4]=2[O:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27598462-(1,3-Dioxaindan-5-yl)ethan-1-ol

Produkt 1

HCID 186255853,4-Methylenedioxyphenethyl mesylateAusbeute 100,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of alcohol (a) (1.90 g, 11 mmol) in dichloromethane (25 ml) was treated at 0° C. with triethylamine (1.9 ml, 13.7 mmol) and methanesulfonyl chloride (1.1 ml, 13.7 mmol). After 1.5 hours at room temperature the mixture was partitioned between dichloromethane and water. The organic extract was dried and evaporated to give a yellow oil (2.7 g, 96%).

Aufarbeitung

  1. customAfter 1.5 hours at room temperature the mixture was partitioned between dichloromethane and water
  2. extractionThe organic extract
  3. customwas dried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-411bf821d8784d468f227ada430abb2a
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07186730B2

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