Hydrazine hydrate (1:1) → HCID 178477869, Verbindung
Reaktionsgleichung
Cl[C:2]1[C:7]([C:8]([C:10]2[CH:14]=[CH:13][NH:12][CH:11]=2)=O)=[CH:6][CH:5]=[C:4]([Cl:15])[N:3]=1.O.[NH2:17][NH2:18]>C(O)C>[Cl:15][C:4]1[N:3]=[C:2]2[NH:17][N:18]=[C:8]([C:10]3[CH:14]=[CH:13][NH:12][CH:11]=3)[C:7]2=[CH:6][CH:5]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
A mixture of (2,6-dichloro-pyridin-3-yl)-(1H-pyrrol-3-yl)-methanone (300 mg) and hydrazine hydrate (0.2 mL) in ethanol (10 mL) was heated at 90° C. for 20 hours. The reaction was concentrated to 6 mL, diluted with water (2 mL) and cooled. The precipitate was collected and dried to give 160 mg of the titled compound.
Aufarbeitung
- concentrationThe reaction was concentrated to 6 mL
- additiondiluted with water (2 mL)
- temperaturecooled
- customThe precipitate was collected
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-e8c5a7615b094a128dc5606ce408285f
- Quelldatensatz
- uspto-grants-2007_03
- Patentnummer
- US07186716B2
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