Hydrazine hydrate (1:1) → HCID 178527562, Verbindung

HRID 456642Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 456642
[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]([C:19]2[C:20](Cl)=[N:21][CH:22]=[CH:23][CH:24]=2)=O)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:27][NH2:28]>C(O)C>[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]2[C:19]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:28][N:27]=2)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 865922435-(2-chloro-pyridine-3-carbonyl)1H-pyrrole-3-sulfonic acid benzylamide

Produkt 1

HCID 178527562HCID 178527562, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-3-sulfonic acid benzylamide (100 mg), hydrazine hydrate (excess) in ethanol (10 mL) was heated at 80° C. for 48 hours. The reaction was concentrated, mixed with water, the precipitate was filtered off, the filtrate was washed with dilute HCl, water, dried and concentrated to give the titled compound as a light yellow solid.

Aufarbeitung

  1. concentrationThe reaction was concentrated
  2. additionmixed with water
  3. filtrationthe precipitate was filtered off
  4. washthe filtrate was washed with dilute HCl, water
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-2a1b0aeb7f674e26a6736595803bf2a1
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07186716B2

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