6-Methoxy-2-methylsulfanyl-quinoline → 2-Methanesulfonyl-6-methoxy-quinoline

HRID 456987

Reaktionsgleichung

Reaktionsgleichung von HRID 456987
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8](SC)[CH:7]=[CH:6]2.CO.[CH2:17]1COCC1.O[O:23][S:24]([O-:26])=O.[K+]>O>[CH3:17][S:24]([C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[N:9]=1)(=[O:26])=[O:23]

Komponenten

5

Edukt 3

HCID 112411826-Methoxy-2-methylsulfanyl-quinolineHCID 21899815MeOH tetrahydrofuranHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 112533772-Methanesulfonyl-6-methoxy-quinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A solution of 6-methoxy-2-methylsulfanyl-quinoline (1.0 g, 5 mmoles) in 100 mL 1:1 MeOH/THF was treated with a solution of 5 g OXONE™ in 50 mL water and stirred for 2–3 hours until the oxidation is complete. The mixture is poured into water and extracted with EtOAc. The organic phase is dried and evaporated to yield 2-methanesulfonyl-6-methoxy-quinoline as a crystalline white product.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. customThe organic phase is dried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-97a0ad9152da4e2d945150aacb685751
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07186840B2

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