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N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide → Bicalutamide

HRID 457265
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 457265
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2([CH3:15])[CH2:14][O:13]2)=[O:11])=[CH:5][C:4]=1[C:16]([F:19])([F:18])[F:17])#[N:2].[F:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([O-:29])=[O:28])=[CH:23][CH:22]=1.[Na+]>C(Cl)(Cl)Cl.O.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH3:15][C:12]([OH:13])([C:10]([NH:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:5]=1)=[O:11])[CH2:14][S:27]([C:24]1[CH:23]=[CH:22][C:21]([F:20])=[CH:26][CH:25]=1)(=[O:29])=[O:28]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 2

HCID 10149314N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamideHCID 236662204-fluorobenzenesulfinic acid sodium salt

Produkt 1

HCID 2375Bicalutamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 74236Tetrabutylammonium BromideKatalysatorHCID 962WaterLösungsmittel
HCID 6212
Chloroform
Lösungsmittel
2×

Versuchsvorschrift

0.500 g of the epoxyamide (5A) was dissolved in a mixture of 40 ml of chloroform and 40 ml of water and 371 mg of sodium p-fluorobenzenesulfinate was added. Subsequently, 298 mg of tetrabutylammonium bromide was added. The reaction mixture was heated till reflux, while stirring vigorously. The reaction was monitored with HPLC. After 96 hours of reflux, the reaction mixture was cooled to room temperature. 20 ml of chloroform was added and the organic layer was washed with 3×50 ml of water, dried (Na2SO4) and evaporated to dryness. Yield: 860 mg. Purification of the crude product by column chromatography (Merck silica gel 60; eluent: heptane/ethyl acetate=1/1) afforded bicalutamide as white solid. Isolated yield: 380 mg (48%). 1H-NMR: confirmed the structure.

Aufarbeitung

  1. additionwas added
  2. temperatureThe reaction mixture was heated
  3. temperaturetill reflux
  4. temperatureAfter 96 hours of reflux
  5. washthe organic layer was washed with 3×50 ml of water
  6. dry with materialdried (Na2SO4)
  7. customevaporated to dryness
  8. customPurification of the crude product by column chromatography (Merck silica gel 60; eluent: heptane/ethyl acetate=1/1)

Quellen und Nachweise

ORD-Eintrag
ord-fcbf07e29a3d498683bd5248bede777c
Quelldatensatz
uspto-grants-2007_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07186854B2

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