Lithium Hydroxide → 5-Hydroxyisophthalic acid
Reaktionsgleichung
[OH:1][C:2]1[CH:3]=[C:4]([C:12]([O:14]C)=[O:13])[CH:5]=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Li+]>C1COCC1>[OH:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[CH:5]=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
To dimethyl 5-hydroxyisophthalate (4.0 g, 19.03 mmol, 1.00 equiv) in THF (10 mL) was added lithium hydroxide (20 mL, 2M in water) and the resulting solution was stirred overnight at 40° C. The mixture concentrated under vacuum to remove the organic solvents and then the pH of the solution was adjusted to ˜2 with 6N hydrochloric acid. The resulting solids were collected by filtration and dried in a vacuum oven to afford 2.0 g (58%) of 5-hydroxyisophthalic acid as a white solid.
Aufarbeitung
- concentrationThe mixture concentrated under vacuum
- customto remove the organic solvents
- filtrationThe resulting solids were collected by filtration
- customdried in a vacuum oven
Quellen und Nachweise
- ORD-Eintrag
- ord-6caa6e20c67a41f6b1ca7271b7a871a0
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08541448B2
Notizen zur Reaktion
Wird geladen…