Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate → 6-Trifluoromethyloxindole

HRID 457634

Reaktionsgleichung

Reaktionsgleichung von HRID 457634
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[CH2:14][C:15]([O:17]C)=O)([O-])=O>[Pd]>[F:11][C:10]([F:13])([F:12])[C:8]1[CH:9]=[C:4]2[C:5]([CH2:14][C:15](=[O:17])[NH:1]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 83569Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

Produkt 1

HCID 6084876-Trifluoromethyloxindole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Methyl 2-nitro-4-trifluoromethylphenylacetate (26 mg) was hydrogenated over 10% palladium on carbon and then heated at 100° C. for 3 hours. The catalyst was removed by filtration and the solvent evaporated to give the title compound.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8297bf6395c54394842ec4283eb5610d
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189721B2

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