Carbonyl bromide → HCID 22254060, Verbindung

HRID 457682

Reaktionsgleichung

Reaktionsgleichung von HRID 457682
[NH2:1][C:2]([NH2:4])=[S:3].[CH:5]([C:8]([NH:10][CH:11]1[CH2:16][CH2:15][CH:14](N(C)C(N)=S)[CH2:13][CH2:12]1)=[O:9])([CH3:7])[CH3:6].Br[C:23](Br)=O.C(N(C(C)C)CC)(C)C>CCO>[CH:5]([C:8]([NH:10][CH:11]1[CH2:16][CH2:15][CH:14]([CH2:23][NH:1][C:2]([NH2:4])=[S:3])[CH2:13][CH2:12]1)=[O:9])([CH3:7])[CH3:6]

Komponenten

6

Edukt 4

HCID 79057Carbonyl bromideHCID 81531DiisopropylethylamineHCID 2723790ThioureaHCID 17946834HCID 17946834, Verbindung

Produkt 1

HCID 22254060HCID 22254060, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A thiourea such as N-[4-(isopropylformylamino)cyclohexyl]-methylthiourea (0.029 mmol, 1 equivalent), a bromoketone (0.044 mmol, 1.5 equivalent) and 2 equivalents of diisopropylethyl amine in 10 ml of EtOH were heated at reflux temperature for 2 days. The reaction mixture was concentrated in vacuo and the crude product chromatographed (silica) to obtain the desired product. This procedure was used to prepare examples 101–102.

Aufarbeitung

  1. temperatureat reflux temperature for 2 days
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe crude product chromatographed (silica)

Quellen und Nachweise

ORD-Eintrag
ord-ee9773061a0943b58a1861525ed730a9
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189720B2

Verknüpfte Notizen

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