6-Fluoroindole → 6-fluoro-3-(piperidin-4-yl)-1H-indole

HRID 457790

Reaktionsgleichung

Reaktionsgleichung von HRID 457790
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl.O.[NH:13]1[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]1>[Pt](=O)=O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:16]3[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 3512786-FluoroindoleHCID 2723901Piperonylamine

Produkt 1

HCID 110960776-fluoro-3-(piperidin-4-yl)-1H-indoleAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 345198Adams' catalystKatalysator

Versuchsvorschrift

This compound was prepared following the procedure described in example 1 (parts A and B) starting with 1 g (7.4 mmol) of 6-fluoroindol and 2.84 g (18.5 mmol) of 4-piperidone monohydrate hydrochloride. In this case, the hydrogenation step took place for 1 hour at 30 psi and the catalyst used was platinum (IV) oxide. 0.640 g (51% yield) of 6-fluoro-3-piperidin-4-yl-1H-indole were obtained.

Aufarbeitung

  1. customThis compound was prepared
  2. customfor 1 hour

Quellen und Nachweise

ORD-Eintrag
ord-a88e4eccea67484fb2055c509818042c
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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