Hydrochloric Acid → HCID 11298899, Verbindung

HRID 458130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 458130
[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([N+:13]([O-])=O)[CH:4]=1)#[N:2].[H][H].[ClH:18]>O.[OH-].[Pd+2].[OH-]>[Cl-:18].[NH2:13][C:5]1[CH:4]=[C:3]([CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])[CH2:1][NH3+:2]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 11356202Methyl 4-cyano-2-nitrobenzoateHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 11298899HCID 11298899, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

18.5 g (0.09 mol) of methyl 4-cyano-2-nitrobenzoate and 0.93 g of palladium hydroxide (20% on charcoal) are suspended in a mixture of 8 ml of concentrated hydrochloric acid (30% strength) and 315 ml of water in a Hastelloy stirred autoclave. Then, the mixture is hydrogenated at a hydrogen pressure of 17 bar until the hydrogen uptake is complete. After the pressure in the autoclave has been released and the catalyst filtered off, the filtrate is evaporated completely. This gives 19.5 g (97% strength) of 3-amino-4-methoxycarbonylbenzylammonium chloride of melting point 200–205° C.

Aufarbeitung

  1. filtrationthe catalyst filtered off
  2. customthe filtrate is evaporated completely

Quellen und Nachweise

ORD-Eintrag
ord-f545a9bf5ce34847812983b2363c5573
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189848B2

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