Trifluoroacetic acid → HCID 178482071, Verbindung

HRID 45867Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 45867
COC1C=CC(C[N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH3:20])[CH:14]=3)[C:10]([C:21]3[CH:22]=[C:23]([NH:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=4)=[O:29])[CH:24]=[CH:25][CH:26]=3)=[N:9]2)=CC=1.FC(F)(F)C(O)=O>C(OCC)C>[CH3:20][NH:19][C:15]1[CH:14]=[C:13]([C:11]2[C:10]([C:21]3[CH:22]=[C:23]([NH:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:38])[F:39])=[CH:33][CH:32]=4)=[O:29])[CH:24]=[CH:25][CH:26]=3)=[N:9][NH:8][CH:12]=2)[CH:18]=[CH:17][N:16]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 671843231-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea

Produkt 1

HCID 178482071HCID 178482071, VerbindungAusbeute 63,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

200 mg (0.35 mmol) of 1-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea were dissolved with 10 ml of trifluoroacetic acid and the solution was stirred at 70° C. for 6 hours. The solvent was then evaporated and the residue taken up with dichloromethane and washed with aqueous sodium hydrogenocarbonate. The organic layer was dried over sodium sulphate and evaporated again, affording, after trituration with diethylether, 100 mg (63%) of the title compound.

Aufarbeitung

  1. customThe solvent was then evaporated
  2. washwashed with aqueous sodium hydrogenocarbonate
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. customevaporated again
  5. customaffording

Quellen und Nachweise

ORD-Eintrag
ord-0881357f3db34e27bcd454017bf8c670
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541575B2

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