tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylate → Ethyl 1-((1,1-dimethylethoxy)carbonyl)-4-piperidineacetate

HRID 458753Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 458753
[CH2:1]([O:3][C:4](=[O:19])[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:19])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)[CH3:2]

Komponenten

5

Edukt 2

HCID 10333298tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 9993342Ethyl 1-((1,1-dimethylethoxy)carbonyl)-4-piperidineacetateAusbeute 93,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 355 mg of t-butyl 4-(2-ethoxy-2-oxoethylidene)tetrahydropyridine-1(2H)-carboxylate in 10 ml of methanol, 50 mg of 10% palladium-on-carbon catalyst was added and stirred for 13 hours in 3 atmospheres' hydrogen pressure. Filtering the catalyst off, the solvent was distilled off under reduced pressure to provide 334 mg of the title compound.

Aufarbeitung

  1. filtrationFiltering the catalyst off, the solvent
  2. distillationwas distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-86514213e8594a5aaa21e599e5e07c95
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192969B2

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