7-Hydroxyflavone → (2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-propoxy]-phenyl}-propionic acid

HRID 459134

Reaktionsgleichung

Reaktionsgleichung von HRID 459134
[OH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1.O[C:20]1[CH:29]=[C:28]2[C:23]([C:24](=[O:36])[CH:25]=[C:26]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[O:27]2)=[CH:22][CH:21]=1>>[CH3:18][O:17][C@@H:13]([CH2:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][O:1][C:20]2[CH:29]=[C:28]3[C:23]([C:24](=[O:36])[CH:25]=[C:26]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[O:27]3)=[CH:22][CH:21]=2)=[CH:7][CH:8]=1)[C:14]([OH:16])=[O:15]

Komponenten

3

Edukt 2

HCID 52818947-HydroxyflavoneHCID 69424952(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid

Produkt 1

HCID 58822836(2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-propoxy]-phenyl}-propionic acid

Versuchsvorschrift

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 7-hydroxyflavone and cleavage from the resin (Standard Procedure G) gave an oily solid.

Aufarbeitung

  1. customgave an oily solid

Quellen und Nachweise

ORD-Eintrag
ord-7a4feb1f8f80404081c313555e183b4e
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

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