Sodium Hydroxide → (2S)-2-Methoxy-3-(4-{3-[4-(3-phenyl-propionyl)-phenoxy]-propoxy}-phenyl)-propionic acid

HRID 459256

Reaktionsgleichung

Reaktionsgleichung von HRID 459256
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[OH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:37])[CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:24][CH:23]=1.[OH-].[Na+]>>[CH3:19][O:18][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:21][C:22]2[CH:23]=[CH:24][C:25]([C:28](=[O:37])[CH2:29][CH2:30][C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[CH:26][CH:27]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:20]

Komponenten

4

Edukt 3

HCID 14798Sodium HydroxideHCID 144161631-(4-Hydroxyphenyl)-3-phenylpropan-1-oneHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Produkt 1

HCID 10204975(2S)-2-Methoxy-3-(4-{3-[4-(3-phenyl-propionyl)-phenoxy]-propoxy}-phenyl)-propionic acid

Versuchsvorschrift

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 1-(4-Hydroxy-phenyl)-3-phenyl-propan-1-one from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C28H30O6 [M+NH4]+: 485 [M+H]+: 463.

Aufarbeitung

  1. customThe compound thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-c7bb5812cc4748d6a8e2dd908bf45f85
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

Verknüpfte Notizen

Wird geladen…