Ammonium Chloride → 1-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol

HRID 460309

Reaktionsgleichung

Reaktionsgleichung von HRID 460309
[Br:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH:11]=[O:12])[CH:3]=1.[CH:13]([Mg]Cl)([CH3:15])[CH3:14].[Cl-].[NH4+]>CCOCC>[Br:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH:11]([OH:12])[CH:13]([CH3:15])[CH3:14])[CH:3]=1

Komponenten

5

Edukt 3

HCID 25517Ammonium ChlorideHCID 23202437-Bromo-1,3-dioxaindane-5-carbaldehydeHCID 178418918HCID 178418918, Verbindung

Produkt 1

HCID 184453941-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-olAusbeute 96,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 7-bromo-benzo[1,3]dioxole-5-carbaldehyde (437 mg, 1.91 mmol) in dry ether (6 mL) was added slowly under argon at −30° C. isopropylmagnesium chloride (1.15 mL, 2.0 M in ether, 2.29 mmol) and the solution stirred for 30 minute. A solution of aqueous ammonium chloride was added and the layers separated. The aqueous layer was extrated with ethyl acetate and the organic combined and washed with water, brine, dried (MgSO4), filtered and evaporated to give 503 mg of 1-(7-bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol.

Aufarbeitung

  1. customthe layers separated
  2. washwashed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2cb68651744b4569b1e4bc0ac9ee3e60
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07196108B2

Verknüpfte Notizen

Wird geladen…