Water → tert-Butyl [2-(5-oxo-4,5-dihydro[1,3,4]oxadiazol-2-yl)thiophen-3-yl]carbamate

HRID 460314Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 460314
[C:1](Cl)(Cl)=[O:2].[C:5]([O:9][C:10]([NH:12][C:13]1[CH:17]=[CH:16][S:15][C:14]=1[C:18]([NH:20][NH2:21])=[O:19])=[O:11])([CH3:8])([CH3:7])[CH3:6].O>C1COCC1>[O:2]=[C:1]1[O:19][C:18]([C:14]2[S:15][CH:16]=[CH:17][C:13]=2[NH:12][C:10](=[O:11])[O:9][C:5]([CH3:8])([CH3:6])[CH3:7])=[N:20][NH:21]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 6371PhosgeneHCID 184459443-(tert-Butoxycarbonylamino)thiophene-2-carboxylic hydrazide

Produkt 1

HCID 86760474tert-Butyl [2-(5-oxo-4,5-dihydro[1,3,4]oxadiazol-2-yl)thiophen-3-yl]carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

4 ml of a 20% toluenic phosgene solution are added dropwise to a solution of 240 mg of 3-(tert-butoxycarbonylamino)thiophene-2-carboxylic hydrazide in 5 ml of THF and the mixture is stirred at RT. After one hour, the mixture is admixed with 10 ml of water and, after brief digestion, extracted with ethyl acetate. After the ethyl acetate phase has been dried over sodium sulfate, the mixture is concentrated under reduced pressure and the remaining residue is used further without further purification.

Aufarbeitung

  1. extractionafter brief digestion, extracted with ethyl acetate
  2. dry with materialAfter the ethyl acetate phase has been dried over sodium sulfate
  3. concentrationthe mixture is concentrated under reduced pressure
  4. customthe remaining residue is used further without further purification

Quellen und Nachweise

ORD-Eintrag
ord-37189ac45f724e52911353c37347c860
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07196114B2

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