Cyclohexyl methyl ketone → 1-Cyclohexyl-3-dimethylamino-propenone

HRID 460700

Reaktionsgleichung

Reaktionsgleichung von HRID 460700
[CH3:1][C:2]([CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=O.C([O:14][CH:15](N(C)C)[N:16]([CH3:18])[CH3:17])(C)(C)C>>[CH3:17][N:16]([C:15](/[CH:1]=[CH:2]/[CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:14])[CH3:18]

Komponenten

3

Edukt 2

HCID 13207Cyclohexyl methyl ketoneHCID 79885tert-Butoxy bis(dimethylamino)methane

Produkt 1

HCID 110952411-Cyclohexyl-3-dimethylamino-propenoneAusbeute 93 %

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 3.0 g (23.8 mmol) of cyclohexyl methyl ketone and 4.56 g (26.2 mmol) of t-butoxybis(dimethylamino)methane (Bredereck's reagent) was stirred at 60° C. overnight. The reaction mixture was then concentrated to give 4.0 g (93% yield) of 1-cyclohexyl-3-dimethylamino-propenone as an orange oil as indicated by 1H NMR. This product was used in the next reaction without any further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated

Quellen und Nachweise

ORD-Eintrag
ord-cbb6055354164bfe8509e4c4b6195761
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07196111B2

Verknüpfte Notizen

Wird geladen…