Ethyl Bromide → HCID 22759318, Verbindung

HRID 460847Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 460847
[Mg].BrCC.[CH2:5]([O:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][O:10]1)[C:6]#[CH:7].[F:15][C:16]1[CH:25]=[CH:24][C:19]([O:20][CH2:21][CH:22]=[O:23])=[CH:18][CH:17]=1.[Cl-].[NH4+]>O1CCCC1.O>[O:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]1[O:8][CH2:5][C:6]#[C:7][CH:22]([OH:23])[CH2:21][O:20][C:19]1[CH:24]=[CH:25][C:16]([F:15])=[CH:17][CH:18]=1

Komponenten

8

Edukt 5

HCID 6332Ethyl BromideHCID 25517Ammonium ChlorideHCID 98609Tetrahydro-2-(2-propynyloxy)-2H-pyranHCID 5462224MagnesiumHCID 110518692-(4-Fluorophenoxy)acetaldehyde

Produkt 1

HCID 22759318HCID 22759318, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To the Grignard reagent prepared from magnesium (12.2 g., 0.5 mole) and bromoethane (54.5 g., 0.5 mole) in tetrahydrofuran (400 ml.) is added, dropwise, during 30 minutes, a solution of tetrahydro-2-(2-propynyloxy)-2H-pyran (67.3 g., 0.5 mole) in tetrahydrofuran (50 ml.). The mixture is stirred at room temperature for 1 hour and then treated, dropwise, during 1 hour with 4-fluorophenoxy-acetaldehyde (61.6 g., 0.4 mole). The resulting mixture is heated at reflux for 1 hour, then cooled and poured into an ice cold saturated solution of ammonium chloride in water.

Aufarbeitung

  1. additionis added
  2. additiontreated
  3. temperatureThe resulting mixture is heated
  4. temperatureat reflux for 1 hour
  5. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-7c743f7eab3a4edb90280485f0b1b5f1
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061643

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