Acetic Acid → 2,3,4-Tribromo-5-(chloromethyl)thiophene

Temperatur

70 °C

4.07 G. (50 mmol) of formalin (37%) and 40 ml. of concentrated hydrochloric acid were added to a solution of 10.2 g. (33.3 mmol) of 3,4,5-tribromothiophene in 20 ml. of acetic acid. The resulting mixture was warmed to 70° C. After 6 hrs., 4.07 g. of formalin were added and heating was continued overnight. The resulting mixture was cooled, poured on ice water and extracted with ether. The organic phase was washed twice with water, sodium bicarbonate and water, dried and evaporated to give crude 2-chloromethyl-3,4,5-tribromothiophene.

1. temperatureheating
2. waitwas continued overnight
3. temperatureThe resulting mixture was cooled
4. additionpoured on ice water
5. extractionextracted with ether
6. washThe organic phase was washed twice with water, sodium bicarbonate and water
7. customdried
8. customevaporated

ORD-Eintrag

ord-408a0434d5404f2d8ed59b0a849175be

Quelldatensatz

uspto-grants-1977_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04061656