Hydrogen Bromide → Bromo-4'-chloro-3'-sulfamoylacetophenone

HRID 461103

Reaktionsgleichung

Reaktionsgleichung von HRID 461103
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[Br:15]Br.Br>C(OCC)(=O)C>[Br:15][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([S:11](=[O:13])(=[O:14])[NH2:12])[CH:4]=1)=[O:10]

Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 24408Bromine2×HCID 126197985-Acetyl-2-chlorobenzene-1-sulfonamide

Produkt 1

HCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4.7 g. of 4'-chloro-3'-sulfamoylacetophenone were suspended in 50 ml of ethyl acetate and to that suspension, some drops of a solution of 3.2 g of bromine were added until the mixture was distinctly brown. The suspension was heated to about 60° - 70° C until the color changed (addition of a drop of 48% hydrobromic acid possible), cooled and the residual amount of the bromine solution was added dropwise at room temperature, while stirring. After distilling off the solvent, 2-bromo-4'-chloro-3'-sulfamoylacetophenone was obtained which melted at 169° C (from n-butanol).

Aufarbeitung

  1. temperatureThe suspension was heated to about 60° - 70° C until the color
  2. temperaturecooled
  3. distillationAfter distilling off the solvent

Quellen und Nachweise

ORD-Eintrag
ord-a22a8f8c63544bef8cdc6f6d728e5041
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061761

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