N,N'-Diethylthiourea → 3-Ethyl-2-ethylimino-4-(4-methyl-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

HRID 461156

Reaktionsgleichung

Reaktionsgleichung von HRID 461156
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH2:16]([NH:18][C:19]([NH:21][CH2:22][CH3:23])=[S:20])[CH3:17]>C(OC(C)C)(C)C>[ClH:1].[CH2:22]([N:21]1[C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=2)([OH:4])[CH2:2][S:20][C:19]1=[N:18][CH2:16][CH3:17])[CH3:23]

Komponenten

4

Edukt 2

HCID 2735009N,N'-DiethylthioureaHCID 136287832-Chloro-4'-methyl-3'-sulfamoylacetophenone

Produkt 1

HCID 227604333-Ethyl-2-ethylimino-4-(4-methyl-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7914Diisopropyl EtherLösungsmittel

Versuchsvorschrift

5 g of 2-chloro-4'-methyl-3'-sulfamoylacetophenone and 2.7 g of 1,3-diethylthiourea were reacted as prescribed in Example 12. After addition of 200 ml of diisopropyl ether the solvent was decanted and the oily end product was crystallized under ethyl acetate heated to 40° to 50° C. Colorless solid body, melting point: 160° C (decomposition).

Aufarbeitung

  1. customwas decanted
  2. customthe oily end product was crystallized under ethyl acetate
  3. temperatureheated to 40° to 50° C

Quellen und Nachweise

ORD-Eintrag
ord-31fcc2290c774320bcc607a62f00ec11
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061761

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