Tert-Butylamine → 3-(Tert-butylsulfamoyl)-4-chlorobenzoic acid

HRID 461172Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461172
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[Cl:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[S:16](Cl)(=[O:18])=[O:17]>C(O)C>[C:1]([NH:5][S:16]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:7]=1[Cl:6])[C:11]([OH:13])=[O:12])(=[O:17])=[O:18])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 6385Tert-ButylamineHCID 756134-Chloro-3-(chlorosulphonyl)benzoic acid

Produkt 1

HCID 23938783-(Tert-butylsulfamoyl)-4-chlorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

To a mixture of 36.5 g (0.5 mol) of tert.-butylamine and 250 ml of ethanol were added 25.5 g (0.1 mol) of 4-chloro-3-chlorosulfonylbenzoic acid in small portions while stirring and cooling, the reaction temperature being maintained at about 30° C. After a dwelling time over night at room temperature, the solvent was distilled off, the residue was dissolved in about 200 ml of water, the pH was adjusted to 1 with concentrated HCl and the crystals were filtered off. Melting point: 250° C.

Aufarbeitung

  1. temperaturecooling
  2. waitAfter a dwelling time over night at room temperature
  3. distillationthe solvent was distilled off
  4. dissolutionthe residue was dissolved in about 200 ml of water
  5. filtrationthe crystals were filtered off

Quellen und Nachweise

ORD-Eintrag
ord-9238b6692c214bc99dc8d0a44ec7240c
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061761

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