8-Chloroisoquinoline hydrochloride → 8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 461481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461481
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2>[Pt](=O)=O.CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2

Komponenten

4

Edukt 1

HCID 123717488-Chloroisoquinoline hydrochloride

Produkt 1

HCID 125950728-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 11.0 g. of 8-chloroisoquinoline hydrochloride in 100 ml. of methanol was hydrogenated at atmospheric pressure over 0.5 g. of platinum dioxide as in Example 9. The mixture was filtered and concentrated to small volume. Ether was added, the mixture was filtered, and the solid recrystallized from ethanol to give 8-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride, m.p. 236°-238.5° C.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated to small volume
  3. additionEther was added
  4. filtrationthe mixture was filtered
  5. customthe solid recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-67733e16e1d044a9b6756f68a15e3c7b
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04062961

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