Hydrochloric Acid → Suprofen

HRID 461716Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461716
CC(N)C1C=CC=CC=1.[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1.Cl>O>[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 70638167(+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

Produkt 1

HCID 5359Suprofen

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1 part of (+)-p-(2-thenoyl)hydratropic acid α-methylbenzylamine is suspended in water and acidified with hydrochloric acid. The product is extracted with ether. The organic layer is washed with water, dried, filtered and evaporated in vacuo. The oily residue solidifies on triturating in petroleumether. The solidified product is filtered off and dried in vacuo at 50° C, yielding (-)-p-(2-thenoyl)hydratropic acid; [α](1% MeOH) = -45.6°.

Aufarbeitung

  1. extractionThe product is extracted with ether
  2. washThe organic layer is washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customon triturating in petroleumether
  7. filtrationThe solidified product is filtered off
  8. customdried in vacuo at 50° C

Quellen und Nachweise

ORD-Eintrag
ord-dae41145302c49b9a7a5189caf9def06
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04064132

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