Tetrahydrofuran → 2-(Bicyclo[2.2.1]hept-7-yl)ethylamine

HRID 461988Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461988
[H-].[Al+3].[Li+].[H-].[H-].[H-].O1CCCC1.[CH:12]12[CH:18]([CH2:19][C:20]([NH2:22])=O)[CH:15]([CH2:16][CH2:17]1)[CH2:14][CH2:13]2>O>[CH:15]12[CH:18]([CH2:19][CH2:20][NH2:22])[CH:12]([CH2:17][CH2:16]1)[CH2:13][CH2:14]2

Komponenten

5

Edukt 3

HCID 8028Tetrahydrofuran2×HCID 21226445Aluminium lithium hydride2×HCID 57053985Bicyclo[2.2.1]hept-7-yl acetamide

Produkt 1

HCID 213919412-(Bicyclo[2.2.1]hept-7-yl)ethylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

0.0425 Mole of lithium aluminum hydride is dissolved in 100 ml. of anhydrous tetrahydrofuran at 0° C, under nitrogen, and then 0.0425 mole of bicyclo[2.2.1]hept-7-yl acetamide in 100 ml. of anhydrous tetrahydrofuran is added dropwise. The mixture is stirred for about 12 hours at room temperature and then about 10 ml. of water is carefully added to decompose excess lithium aluminum hydride (and complex). The mixture is then filtered and the filtrate then dried with potassium hydroxide pellets; filtered and the filtrate distilled, to remove solvent, affording 2-(bicyclo[2.2.1]hept-7-yl)ethylamine.

Aufarbeitung

  1. customat 0° C
  2. filtrationThe mixture is then filtered
  3. dry with materialthe filtrate then dried with potassium hydroxide pellets
  4. filtrationfiltered
  5. distillationthe filtrate distilled
  6. customto remove solvent

Quellen und Nachweise

ORD-Eintrag
ord-b6774ea8d7b94674b29ebc7663e32a37
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04064258

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