3-Chloro-1,2-propanediol → 7-(2,3-Dihydroxy)propoxy-3,4-dihyrocarbostyril

HRID 462050

Reaktionsgleichung

Reaktionsgleichung von HRID 462050
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[CH2:13]([OH:18])[CH:14]([OH:17])[CH2:15]Cl>>[OH:17][CH:14]([CH2:13][OH:18])[CH2:15][O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 72903-Chloro-1,2-propanediolHCID 27857587-Hydroxy-3,4-dihydrocarbostyril

Produkt 1

HCID 213903437-(2,3-Dihydroxy)propoxy-3,4-dihyrocarbostyril

Versuchsvorschrift

In the same manner as described in Example 7, 7-hydroxy-3,4-dihydrocarbostyril was reacted with glycerol α-monochlorohydrin to give 7-(2,3-dihydroxy)propoxy-3,4-dihyrocarbostyril as white needle-like srystals having a melting point of 143° - 144° C.

Quellen und Nachweise

ORD-Eintrag
ord-ea12df6cce4541559ea6ee27b3ce59d5
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04065456

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