1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide → HCID 13092509, Verbindung

HRID 462100

Reaktionsgleichung

Reaktionsgleichung von HRID 462100
Cl.NCC[C:5]1[C:10]([CH2:11][C:12]([OH:14])=O)=[CH:9][CH:8]=[C:7]2[O:15][CH2:16][O:17][C:6]=12.[CH:18]1([N:24]=C=NCCN2CCOCC2)CCCC[CH2:19]1>O>[CH2:16]1[O:17][C:6]2[C:7](=[CH:8][C:9]3[CH2:19][CH2:18][NH:24][C:12](=[O:14])[CH2:11][C:10]=3[CH:5]=2)[O:15]1

Komponenten

4

Edukt 2

HCID 849981-Cyclohexyl-3-(2-morpholinoethyl)carbodiimideHCID 681228476-(2-Aminoethyl)-4,5-methylenedioxy phenyl-acetic acid hydrochloride

Produkt 1

HCID 13092509HCID 13092509, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

Similarly, 0.005 moles (1.3 grams) of 6-(2-aminoethyl)-4,5-methylenedioxy phenyl-acetic acid hydrochloride were dissolved in 15 ml of water and to this solution was added 2.12 grams of 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methotoluenesulfonate in 20 ml of water. After 2 hours at room temperature the precipitate that had formed was filtered off, washed and dried to yield 1,3,4,5-tetrahydro-7,8-methylenedioxy-2H-3-benzazepin-2-one, m.p. 236°-237°. After recrystallization from ether the product melted at 238°-239°.

Aufarbeitung

  1. customAfter 2 hours at room temperature the precipitate that had formed
  2. filtrationwas filtered off
  3. washwashed
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-cedf853a25d14afc95274d438ae71bbb
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04065473

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