Piperidine → 2-[2-(4-Methyl-1-piperazinyl)-5-thiadiazolyl)-1-methyl-5-nitroimidazole

HRID 462235

Reaktionsgleichung

Reaktionsgleichung von HRID 462235
[N:1]1([N:7]2[NH:11][CH:10]=[C:9]([C:12]3[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=3)[S:8]2)[CH2:6][CH2:5]C[CH2:3][CH2:2]1.[CH3:21][N:22]1CCNCC1.N1CCCCC1>>[CH3:21][N:22]1[CH2:5][CH2:6][N:1]([N:7]2[NH:11][CH:10]=[C:9]([C:12]3[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=3)[S:8]2)[CH2:2][CH2:3]1

Komponenten

4

Edukt 3

HCID 8082PiperidineHCID 531671-MethylpiperazineHCID 213908372-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Produkt 1

HCID 213908382-[2-(4-Methyl-1-piperazinyl)-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Versuchsvorschrift

The preparation of the above compound is carried out in the manner described for the 2-piperidino derivative (Example 28), an equivalent of 1-methylpiperazine replacing the piperidine. The crude product is purified by recrystallization from 2-methoxyethanol and melts at 242°-244° C.

Aufarbeitung

  1. customThe preparation of the above compound
  2. customThe crude product is purified by recrystallization from 2-methoxyethanol and melts at 242°-244° C.

Quellen und Nachweise

ORD-Eintrag
ord-174ca826ea4c410fb8561635a96caa59
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04065567

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